(1) Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study.

(2) Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study.

(3) Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial.

Ashwagandha contains numerous bioactive compounds, namely alkaloids, flavonoids, glycosides, steroids, and steroidal lactones. Withanolides are a type of steroidal lactone that are considered to be responsible for most of the plant’s benefits.

One proposed theory is that ashwagandha affects the  HPA axis, which is seen in its ability to affect cortisol levels. A majority of the studies on ashwagandha focus on stress-related conditions, which are frequently associated with cortisol, other neuroendocrine hormones, and neurotransmitters. Much research has been devoted to understanding the ability of ashwagandha to mitigate the effects of stress, which, in turn, could affect other outcomes and or health states. (4) (5) (6) (7)

Ashwagandha has been used for centuries in traditional medicine and is now supported by modern research for its stress- and anxiety-reducing effects. Clinical trials show it can improve sleep quality, mental clarity, and overall well-being, and may also enhance physical performance, muscle strength, and recovery in both athletes and non-athletes.

While its effectiveness is appealing, this can increase the risk of over-reliance. Rather than depending on this supplement, it’s better to use it as a tool to support your overall well-being and unlock your potential.

Larger clinical studies, especially those with standardised formulations and dose regimens, indicate that milder adverse events (e.g., drowsiness or sedation) can still occur. In a more recent systematic review and meta-analysis, the majority of randomized controlled trials reported no adverse events.

it is crucial that individuals with pre-existing conditions or who are taking other medications, consult with their healthcare professional before starting any supplement regimens.

When taking our supplements (or any supplements for that matter), it’s important to consider their impact on your liver, the liver is responsible for metabolising and detoxifying most substances you ingest. If you’re taking multiple supplements at once, be mindful of potential interactions and the cumulative load on your liver.

With Ruuted, we recommend herb cycling  - using them for 8 weeks, then taking a 4-week break - to help prevent tolerance build up and support optimal effectiveness. Cycling herbs helps your body maintain sensitivity to their effects, ensuring you continue to benefit from the herb over time. Taking periodic breaks prevents desensitisation, preserving its long-term effectiveness.

Always consult with a healthcare professional, especially if you have any health concerns or are taking other medications.

(1) The effects of Shilajit supplementation on fatigue-induced decreases in muscular strength and serum hydroxyproline levels

(2) The Human Skeletal Muscle Transcriptome in Response to Oral Shilajit Supplementation

(3) Efficacy of Momiai in Tibia Fracture Repair: A Randomized Double-Blinded Placebo-Controlled Clinical Trial

The principal active compounds in shilajit — fulvic acid, DBPs, and DCPs — are potent antioxidants that seem to enhance the body’s antioxidant capacity and reduce oxidative stress, which may be behind many of the observed effects of shilajit. For example, shilajit has been found to increase blood levels of antioxidant enzymes (e.g., superoxide dismutase, glutathione peroxidase, catalase), increase levels of the body’s own antioxidants (e.g.,glutathione,vitamin C,vitamin E), and reduce malondialdehyde. Shilajit seems to support tissue integrity at least in part by inducing the expression of genes involved in the production of extracellular matrix proteins (e.g.,collagen, elastin, fibronectin) and blood vessel formation. (4) (5)

Shilajit, a mineral-rich resin used for centuries in Ayurvedic, Siberian & Scandinavian medicine, it is valued for its potential to boost energy and endurance. Research suggests shilajit may help reduce inflammation, slow cellular aging, support cognitive function, and relieve symptoms of chronic fatigue and altitude sickness.

But, it is relatively new to scientific studies in Western society, and long-term research in Western populations remains limited. Ensuring your supplement is high quality, pure, and third-party lab tested—like ours—is essential to minimise risks from contaminants. Although cycling shilajit isn’t necessary for everyone, some people choose to do so to avoid potential overuse or tolerance.

it is crucial that individuals with pre-existing conditions or who are taking other medications, consult with their healthcare professional before starting any supplement regimens.

When taking our supplements (or any supplements for that matter), it’s important to consider their impact on your liver, the liver is responsible for metabolising and detoxifying most substances you ingest. If you’re taking multiple supplements at once, be mindful of potential interactions and the cumulative load on your liver.

With Ruuted, we recommend herb cycling  - using them for 8 weeks, then taking a 4-week break - to help prevent tolerance build up and support optimal effectiveness. Cycling herbs helps your body maintain sensitivity to their effects, ensuring you continue to benefit from the herb over time. Taking periodic breaks prevents desensitisation, preserving its long-term effectiveness.

Always consult with a healthcare professional, especially if you have any health concerns or are taking other medications.

(1) Fenugreek and Its Effects on Muscle Performance: A Systematic Review

(2) A fenugreek seed extract selectively reduces spontaneous fat consumption in healthy volunteers

(3) The addition of fenugreek extract (Trigonella foenum-graecum) to glucose feeding increases muscle glycogen resynthesis after exercise

Fenugreek contains a wide range of bioactive compounds, including saponins (notably diosgenin), glycosides, alkaloids, and soluble fibers, which are thought to drive its physiological effects.The furostanolic saponins and glycosides in fenugreek are particularly important for muscle and metabolic health. These compounds are believed to exert anabolic and androgenic effects. (4) (5)

Additionally, fenugreek’s soluble fiber slows carbohydrate absorption, helping regulate blood sugar and cholesterol, while its anti-inflammatory and antioxidant properties protect muscle and other tissues from stress and damage (6)

Fenugreek is widely used for its potential to help regulate blood sugar and cholesterol, support appetite control, and improve muscle strength in those seeking to enhance exercise performance.It is also traditionally used to support lactation and ease menstrual discomfort.

However, the quality and size of modern clinical studies on fenugreek’s benefits vary, and more rigorous research is needed to confirm many of its traditional uses and long-term safety. Mild side effects such as digestive upset are possible, and fenugreek may interact with certain medications or cause allergic reactions in sensitive individuals.

it is crucial that individuals with pre-existing conditions or who are taking other medications, consult with their healthcare professional before starting any supplement regimens.

When taking our supplements (or any supplements for that matter), it’s important to consider their impact on your liver, the liver is responsible for metabolising and detoxifying most substances you ingest. If you’re taking multiple supplements at once, be mindful of potential interactions and the cumulative load on your liver.

With Ruuted, we recommend herb cycling  - using them for 8 weeks, then taking a 4-week break - to help prevent tolerance build up and support optimal effectiveness. Cycling herbs helps your body maintain sensitivity to their effects, ensuring you continue to benefit from the herb over time. Taking periodic breaks prevents desensitisation, preserving its long-term effectiveness.

Always consult with a healthcare professional, especially if you have any health concerns or are taking other medications.

(1) The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms

(2) The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence

(3) Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms

Rhodiola (Rhodiola rosea) contains a diverse array of bioactive compounds, most notably salidroside (also known as rhodioloside), rosavin, rosarin, rosin, and various flavonoids and phenolic acids. Salidroside is the most studied and is thought to be primarily responsible for many of Rhodiola’s effects, including its adaptogenic, anti-fatigue, and neuroprotective properties. (4) (5)

Rhodiola has a long tradition of use in Russia, Scandinavia, and parts of Asia for supporting endurance, resilience, and stress adaptation over extended periods.

However, most modern clinical studies in Western populations have only evaluated its safety and effectiveness for shorter durations Traditional use suggests it is safe for ongoing use, but again, herb cycling and monitoring your body’s responses is important.

it is crucial that individuals with pre-existing conditions or who are taking other medications, consult with their healthcare professional before starting any supplement regimens.

When taking our supplements (or any supplements for that matter), it’s important to consider their impact on your liver, the liver is responsible for metabolising and detoxifying most substances you ingest. If you’re taking multiple supplements at once, be mindful of potential interactions and the cumulative load on your liver.

With Ruuted, we recommend herb cycling  - using them for 8 weeks, then taking a 4-week break - to help prevent tolerance build up and support optimal effectiveness. Cycling herbs helps your body maintain sensitivity to their effects, ensuring you continue to benefit from the herb over time. Taking periodic breaks prevents desensitisation, preserving its long-term effectiveness.

Always consult with a healthcare professional, especially if you have any health concerns or are taking other medications.

(1) Available chemical constituents and activities of Ganoderma lucidum (Lingzhi or red Reishi) utilizing in disease treatment: A mini review

(2) Emerging Roles of Ganoderma Lucidum in Anti-Aging

(3) A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia

Reishi mushroom (Ganoderma lucidum) contains a rich array of bioactive compounds, primarily polysaccharides (notably beta-glucans), triterpenoids, sterols, proteins, and phenolic compounds.The polysaccharides are best known for their immune-modulating effects—they enhance the activity of white blood cells such as macrophages and natural killer cells.

Mechanistically, reishi’s polysaccharides and triterpenoids work by modulating immune cell signaling, reducing oxidative stress, and inhibiting inflammatory pathways. These actions may explain why reishi is traditionally used to support immunity, reduce fatigue, and promote longevity. (4) (5)

Reishi mushroom has been revered for centuries in traditional Chinese and Japanese medicine, earning the nickname "the mushroom of immortality" for its role in promoting health and longevity. In Japan, it remains widely used and is even incorporated alongside standard cancer treatments, highlighting its importance in both traditional and modern healthcare.

However, most modern wester studies are small and preliminary, partly because reishi is relatively new to Western medicine and research. As a result, more rigorous clinical trials are needed to confirm its benefits and long-term safety.

it is crucial that individuals with pre-existing conditions or who are taking other medications, consult with their healthcare professional before starting any supplement regimens.

When taking our supplements (or any supplements for that matter), it’s important to consider their impact on your liver, the liver is responsible for metabolising and detoxifying most substances you ingest. If you’re taking multiple supplements at once, be mindful of potential interactions and the cumulative load on your liver.

With Ruuted, we recommend herb cycling  - using them for 8 weeks, then taking a 4-week break - to help prevent tolerance build up and support optimal effectiveness. Cycling herbs helps your body maintain sensitivity to their effects, ensuring you continue to benefit from the herb over time. Taking periodic breaks prevents desensitisation, preserving its long-term effectiveness.

Always consult with a healthcare professional, especially if you have any health concerns or are taking other medications.

(1) Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract

(2) The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

(3) The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects

The exact mechanisms by which Bacopa monniericonfers any potential benefits are not fully understood, but they are likely a by product of the main active components of Bacopa monnieri, particularly saponins (e.g., bacoside-A and bacoside-B), alkaloids, and polyphenols. In vitro studies find that bacosides could be neuroprotective and may actually enhance neurotransmission and synaptic activity.

Bacosides may also modulate stress hormones within the brain and positively interact with the serotonin, dopamine, and cholinergic systems, which helps to explain the possible mood-related effects. (4)

Brahmi (Bacopa monnieri) has a long history of use in Ayurvedic medicine, traditionally valued for its ability to enhance memory, learning, and mental clarity. Modern research suggests that brahmi may improve memory, attention, and information processing, especially in healthy adults and older populations.

While it is supported by multiple randomized controlled trials and shows promise for brain health, more large-scale, high-quality studies are needed to fully establish its benefits and long-term safety.

it is crucial that individuals with pre-existing conditions or who are taking other medications, consult with their healthcare professional before starting any supplement regimens.

When taking our supplements (or any supplements for that matter), it’s important to consider their impact on your liver, the liver is responsible for metabolising and detoxifying most substances you ingest. If you’re taking multiple supplements at once, be mindful of potential interactions and the cumulative load on your liver.

With Ruuted, we recommend herb cycling  - using them for 8 weeks, then taking a 4-week break - to help prevent tolerance build up and support optimal effectiveness. Cycling herbs helps your body maintain sensitivity to their effects, ensuring you continue to benefit from the herb over time. Taking periodic breaks prevents desensitisation, preserving its long-term effectiveness.

Always consult with a healthcare professional, especially if you have any health concerns or are taking other medications.